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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGF1R
All Species:
28.18
Human Site:
S316
Identified Species:
62
UniProt:
P08069
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08069
NP_000866.1
1367
154793
S316
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
Chimpanzee
Pan troglodytes
XP_510613
1364
154513
S316
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
Rhesus Macaque
Macaca mulatta
XP_001100407
1367
154946
S316
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
Dog
Lupus familis
XP_545828
1367
154872
S316
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
Cat
Felis silvestris
Mouse
Mus musculus
Q60751
1373
155770
T316
S
G
F
I
R
N
S
T
Q
S
M
Y
C
I
P
Rat
Rattus norvegicus
P24062
1370
155377
T316
S
G
F
I
R
N
S
T
Q
S
M
Y
C
I
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P08941
2311
260942
A683
P
Y
I
L
A
V
G
A
E
G
L
W
K
Q
R
Frog
Xenopus laevis
O73798
1358
153845
S312
S
G
Y
M
L
N
K
S
Q
S
M
T
C
S
P
Zebra Danio
Brachydanio rerio
NP_694500
1405
158428
T319
P
G
F
T
R
N
E
T
L
S
M
F
C
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P09208
2144
239757
E630
P
T
G
Y
Q
K
S
E
N
K
R
M
C
E
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q968Y9
1846
207106
D478
D
G
Y
Q
I
N
P
D
D
H
R
E
C
R
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
98.2
N.A.
95.6
95.7
N.A.
N.A.
21.3
75.5
66.6
N.A.
26.8
N.A.
27
N.A.
Protein Similarity:
100
99.7
99.6
98.8
N.A.
97.8
98
N.A.
N.A.
35.5
85.9
79.2
N.A.
40.3
N.A.
41.5
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
6.6
60
46.6
N.A.
13.3
N.A.
20
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
40
73.3
60
N.A.
20
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
91
0
0
% C
% Asp:
10
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
10
10
0
0
10
0
10
0
% E
% Phe:
0
0
64
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
82
10
0
0
0
46
0
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
10
55
10
0
0
0
0
0
0
0
0
55
0
% I
% Lys:
0
0
0
0
0
10
10
0
0
10
0
0
10
0
10
% K
% Leu:
0
0
0
10
10
0
0
0
10
0
10
0
0
0
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
73
10
0
0
0
% M
% Asn:
0
0
0
0
0
82
0
0
10
0
0
0
0
0
0
% N
% Pro:
28
0
0
0
0
0
10
0
0
0
0
0
0
0
73
% P
% Gln:
0
0
0
10
10
0
0
0
64
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
64
0
0
0
0
0
19
0
0
10
10
% R
% Ser:
64
0
0
0
0
0
28
46
0
73
0
0
0
19
0
% S
% Thr:
0
10
0
10
0
0
0
28
0
0
0
10
0
0
0
% T
% Val:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
0
10
19
10
0
0
0
0
0
0
0
55
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _